Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657043 | 0.79 | HSPB1 (0.43) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL3056900 | 0.70 | ALDH1A1 (0.42) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL6255747 | 0.69 | MAPT (0.50) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL3062661 | 0.68 | HSPB1 (0.50) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL5561358 | 0.68 | CYP1A2 (0.49) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL27691836 | 0.68 | CACNA1C (0.39) | MAPTKDM4EKMT2A | |
| SCHEMBL9905744 | 0.68 | HSPB1 (0.47) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL9905753 | 0.68 | HSPB1 (0.45) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL1978695 | 0.67 | KEAP1 (0.59) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 | |
| SCHEMBL6795644 | 0.67 | HSPB1 (0.56) | MAPTALDH1A1KDM4EL3MBTL1HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207773-A2 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009057811-A2 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-05-07 | — | — | WO | disclosed |