Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662346 | 0.84 | KMT2A (0.45) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL3661255 | 0.81 | CTSC (0.47) | CTSCMCHR1PAX8 | |
| SCHEMBL2076519 | 0.81 | CTSC (0.64) | CTSC | |
| SCHEMBL3656005 | 0.80 | CTSC (0.42) | CTSC | |
| SCHEMBL3652410 | 0.78 | CTSC (0.42) | CTSCMCHR1USP30DPP4DPP8 | |
| SCHEMBL3661348 | 0.74 | FKBP1A (0.39) | MMP13DPP4DPP7 | |
| SCHEMBL3702610 | 0.74 | CTSC (0.41) | CTSCMMP13 | |
| SCHEMBL3688512 | 0.73 | CTSC (0.41) | CTSCMMP13 | |
| SCHEMBL3657032 | 0.73 | CTSC (0.49) | CTSC | |
| SCHEMBL3660901 | 0.72 | CTSS (0.48) | MCHR1MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231597-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | AstraZeneca AB (SE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009074829-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | WO | disclosed |