SCHEMBL365787

SCHEMBL365787

O=P(O)(OBr)Oc1c[nH]c2cccc(Cl)c12

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.48
GPR84 Q9NQS5 1/20 0.42
HTR2A P28223 3/20 0.38
HTR1A P08908 1/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
IDO1 P14902 1/20 0.35
SLC6A4 P31645 1/20 0.35
ERCC5 P28715 1/20 0.33
FEN1 P39748 1/20 0.33
PTGER3 P43115 2/20 0.32
TERT O14746 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
CYP2A6 P11509 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrazole SCHEMBL1636739 0.88 NR4A2 (0.39) NR4A2GPR84HTR2AHTR1AHTR2C
SCHEMBL5366433 0.85 NR4A2 (0.52) NR4A2GPR84HTR2AHTR1AHTR2C
SCHEMBL5617466 0.82 NR4A2 (0.51) NR4A2GPR84HTR2AHTR1AHTR2C
SCHEMBL28034562 0.77 SLC22A6 (0.50) NR4A2GPR84SMN1; SMN2CYP2A6
SCHEMBL10791070 0.74 SMN1; SMN2 (0.56) GPR84SMN1; SMN2LMNA
Phosphoric Acid SCHEMBL6340345 0.71 GPR84 (0.50) NR4A2GPR84HTR2AHTR2CHTR2B
SCHEMBL3362175 0.71 SLC22A6 (0.58) NR4A2GPR84IDO1SLC6A4ERCC5
SCHEMBL28337297 0.71 NR4A2 (0.55) NR4A2GPR84HTR2AHTR1AHTR2C
SCHEMBL8981082 0.70 DAO (0.47) SMN1; SMN2
SCHEMBL10173026 0.70 NR4A2 (0.35) NR4A2HTR2AHTR1AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5658732-A COMPLEXING; PIEZOELECTRIC OSCILLATOR E. I. DU PONT DE NEMOURS AND COMPANY (US) 1997-08-19 US claimed
EP-2971096-A1 CELL PREPARATIONS AND CELL SUPPORTS AND THEIR USE IN THERANOSIS Abbott Molecular Inc. (US) 2016-01-20 EP disclosed
WO-2014159797-A1 CELL PREPARATIONS AND CELL SUPPORTS AND THEIR USE IN THERANOSIS ABBOTT MOLECULAR INC. (US) 2014-10-02 WO disclosed
US-8431355-B2 Using glycosylation profile thyrotropin as diagnostic indicator of thyroid disorders UNIVERSITE DE PROVENCE AIX-MARSEILLE 1 (FR) 2013-04-30 US disclosed
WO-2013036756-A1 VIABLE GRAM NEGATIVE BACTERIA WITH REDUCED PROTEOLYTIC ACTIVITY LACKING OUTER MEMBRANE AGONISTS OF TLR4/MD-2 RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 2013-03-14 WO disclosed
WO-2012008821-A1 RAPID SERODIAGNOSIS OF MELIOIDOSIS UNIVERSITI SAINS MALAYSIA (MY) 2012-01-19 WO disclosed
EP-1027440-B2 INHIBITOR PROTEIN OF THE WNT SIGNAL PATHWAY DEUTSCHES KREBSFORSCH (DE) 2011-09-14 EP disclosed
EP-1379272-B1 MONOCLONAL ANTIBODIES DIRECTED AGAINST MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES NOVARTIS VACCINES & DIAGNOSTIC (US) 2010-01-20 EP disclosed
US-7534444-B2 Molecular mimetics of meningococcal B epitopes which elicit functionally active antibodies NOVATTIS VACCINES AND DIAGNOSTICS, INC. (US) 2009-05-19 US disclosed
EP-1237910-B1 TRP-PROTEIN-RELATED MTR1 PROTEIN AND DNA SEQUENCE CODING THEREFOR UNIV MAINZ JOHANNES GUTENBERG (DE) 2008-09-10 EP disclosed
WO-1998024894-A2 PKD1 FRAGMENTS WITH BONDING AREAS FOR PKD1-SPECIFIC ANTIBODIES Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1998-06-11 WO disclosed
EP-0842278-A1 DNASE-ACTIVE PROTEIN Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1998-05-20 EP disclosed
EP-0840789-A2 TRANSKETOLASE-RELATED PROTEIN Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1998-05-13 EP disclosed
WO-1998018919-A2 GABAA RECEPTOR SUBUNIT EPSILON-RELATED PROTEIN Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1998-05-07 WO disclosed
WO-1997035015-A2 TYROSINE-PHOSPHATASE-RELATED PROTEIN Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1997-09-25 WO disclosed
WO-1997005253-A2 TRANSKETOLASE-RELATED PROTEIN Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1997-02-13 WO disclosed
WO-1996041887-A1 DNASE-ACTIVE PROTEIN Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 1996-12-27 WO disclosed
WO-1995020046-A1 PLANT ACONITASES AND NUCLEIC ACIDS CODING THEREFOR BIOCEM (FR) 1995-07-27 WO disclosed
US-5116732-A Chromagens for Histological Staining FISHER SCIENTIFIC CO. (US) 1992-05-26 US disclosed
EP-0189925-A2 Self-timed immunoassay device GENETIC DIAGNOSTICS CORPORATION (US) 1986-08-06 EP disclosed