Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.32 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.32 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365787 | 0.88 | NR4A2 (0.48) | NR4A2GPR84HTR2AHTR1AHTR2C | |
| SCHEMBL5366433 | 0.75 | NR4A2 (0.52) | NR4A2GPR84HTR2AHTR1AHTR2C | |
| Tetrazole SCHEMBL526238 | 0.75 | HTR2A (0.33) | HTR2AHTR1AHTR2CHTR2B | |
| Tetrazole SCHEMBL6037735 | 0.73 | HTR2A (0.34) | HTR2AHTR1AHTR2CHTR2B | |
| Tetrazole SCHEMBL735500 | 0.73 | HTR2A (0.34) | HTR2AHTR1AHTR2CHTR2B | |
| Tetrazole SCHEMBL225087 | 0.73 | HTR2A (0.34) | HTR2AHTR1AHTR2CHTR2B | |
| SCHEMBL5617466 | 0.72 | NR4A2 (0.51) | NR4A2GPR84HTR2AHTR1AHTR2C | |
| O-Tolylamine SCHEMBL7116171 | 0.68 | HTR2A (0.32) | HTR2AHTR1AHTR2CHTR2B | |
| SCHEMBL28034562 | 0.67 | SLC22A6 (0.50) | NR4A2GPR84 | |
| Tetrazole SCHEMBL27614392 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120232127-A1 | REGULATION OF NEUROTRANSMITTER RELEASE THROUGH ANION CHANNELS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-13 | — | — | US | disclosed |
| EP-2360269-A1 | Lupus anticoagulant testing | American Diagnostica Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20110201668-A1 | REGULATION OF NEUROTRANSMITTER RELEASE THROUGH ANION CHANNELS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-08-18 | — | — | US | disclosed |
| US-20110201017-A1 | LUPUS ANTICOAGULENT TESTING | AMERICAN DIAGNOSTICA, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-7932021-B2 | Lupus anticoagulant testing | AMERICAN DIAGNOSTICA, INC. (US) | 2011-04-26 | — | — | US | disclosed |
| WO-2009096612-A1 | REGULATION OF NEUTROTRANSMITTTER RELEASE THROUGH ANION CHANNELS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-08-06 | — | — | WO | disclosed |
| EP-1920068-A4 | LUPUS ANTICOAGULANT TESTING | AMERICAN DIAGNOSTICA INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1920068-A1 | LUPUS ANTICOAGULANT TESTING | American Diagnostica Inc. (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007018511-A1 | LUPUS ANTICOAGULANT TESTING | AMERICAN DIAGNOSTICA INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| US-20070026467-A1 | Lupus anticoagulant testing | BIOMEDICA DIAGNOSTICS INC. (CA) | 2007-02-01 | — | — | US | disclosed |