Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154700 | 0.91 | GPR84 (0.58) | GPR84NR4A2GAAKDM4EMEN1 | |
| Choline SCHEMBL7041289 | 0.80 | GPR84 (0.40) | GPR84NR4A2GAAKDM4EMEN1 | |
| SCHEMBL8912272 | 0.76 | HTR2C (0.51) | GPR84NR4A2GAAKDM4EMEN1 | |
| SCHEMBL5366433 | 0.76 | NR4A2 (0.52) | GPR84NR4A2KDM4EALDH1A1SLC6A4 | |
| SCHEMBL15826494 | 0.73 | GPR84 (0.64) | GPR84NR4A2GAASLC6A4ERCC5 | |
| SCHEMBL29764387 | 0.73 | GPR84 (0.64) | GPR84NR4A2GAASLC6A4ERCC5 | |
| SCHEMBL29450053 | 0.73 | HTR2C (0.56) | GAAKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL9651757 | 0.73 | HTR2C (0.56) | GAAKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27856195 | 0.71 | GPR84 (0.49) | GPR84NR4A2GAAKDM4EMEN1 | |
| SCHEMBL5617466 | 0.71 | NR4A2 (0.51) | GPR84NR4A2GAASLC6A4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6902586-B2 | Phosphate dye precursors and use thereof for dyeing keratin fibers | L'OREAL (FR) | 2005-06-07 | — | — | US | claimed |
| EP-1273283-B1 | Phosphated dye precursors and their application for dyeing keratinous fibres | OREAL (FR) | 2004-10-06 | — | — | EP | claimed |
| US-20030037387-A1 | Phosphate dye precursors and use thereof for dyeing keratin fibres | L'OREAL (FR) | 2003-02-27 | — | — | US | claimed |
| EP-1273283-A1 | Phosphated dye precursors and their application for dyeing keratinous fibres | L'OREAL (FR) | 2003-01-08 | — | — | EP | claimed |
| US-6902586-B2 | Phosphate dye precursors and use thereof for dyeing keratin fibers | L'OREAL (FR) | 2005-06-07 | — | — | US | disclosed |
| US-20040236082-A1 | Modified staphylococcal enterotoxins and expression systems therefore | IDAHO RESEARCH FOUNDATION, INC. | 2004-11-25 | — | — | US | disclosed |
| WO-2002083169-A9 | MODIFIED STAPHYLOCOCCAL ENTEROTOXINS AND EXPRESSION SYSTEMS THEREFORE | IDAHO RES FOUND (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20030037387-A1 | Phosphate dye precursors and use thereof for dyeing keratin fibres | L'OREAL (FR) | 2003-02-27 | — | — | US | disclosed |
| WO-2002083169-A1 | MODIFIED STAPHYLOCOCCAL ENTEROTOXINS AND EXPRESSION SYSTEMS THEREFORE | IDAHO RESEARCH FOUNDATION, INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| US-4985542-A | GLYCOPROTEINS, UROGENITAL DISORDERS | THE ROCKEFELLER UNIVERSITY (US) | 1991-01-15 | — | — | US | disclosed |
| US-4849339-A | GOODPOSTURE'S | ROCKEFELLER UNIVERSITY (US) | 1989-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030037387-A1 | Phosphate dye precursors and use thereof for dyeing keratin fibres | KRT18, ALPG, ALPP | GPR84 3813/4885NR4A2 3703/4885GAA 2210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.