Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662226 | 0.85 | EPHX1 (0.49) | NPC1RAB9ASMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL3657582 | 0.85 | HRH3 (0.41) | SMN1; SMN2HTTHRH3 | |
| SCHEMBL3650309 | 0.83 | KMT2A (0.50) | NPC1RAB9ASMN1; SMN2EPHX2TSHR | |
| SCHEMBL3658289 | 0.83 | KMT2A (0.45) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL3660320 | 0.81 | HRH3 (0.41) | NPC1RAB9ASMN1; SMN2EPHX2TSHR | |
| SCHEMBL3655153 | 0.81 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HTTPKM | |
| Trifluoroacetic Acid SCHEMBL3660920 | 0.80 | HRH3 (0.38) | HRH3 | |
| SCHEMBL3655033 | 0.80 | HRH3 (0.48) | NPC1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL3652477 | 0.80 | ESR1 (0.45) | NPC1RAB9A | |
| SCHEMBL3658339 | 0.79 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215058-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-11 | — | — | EP | claimed |
| WO-2009052068-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | claimed |
| EP-2215058-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009052068-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |