Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650124 | 0.91 | HSP90AA1 (0.50) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL3656630 | 0.88 | KCNK3 (0.40) | TP53ALDH1A1MAPTKDM4E | |
| SCHEMBL3652477 | 0.88 | ESR1 (0.45) | NPC1RAB9AMEN1KMT2AMAPK14 | |
| SCHEMBL3657680 | 0.87 | RAB9A (0.51) | NPC1RAB9ATP53SMN1; SMN2ALOX15 | |
| Trifluoroacetic Acid SCHEMBL3657556 | 0.86 | HSP90AA1 (0.45) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3650438 | 0.85 | — | — | |
| SCHEMBL3658339 | 0.84 | RAB9A (0.52) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3656237 | 0.83 | MLYCD (0.41) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3655641 | 0.82 | MAPK14 (0.44) | NPC1RAB9ATP53SMN1; SMN2ALOX15 | |
| SCHEMBL3657580 | 0.82 | ESR1 (0.46) | RAB9AMAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |