Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LDLR | P01130 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3656228 | 0.94 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL3653079 | 0.87 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL3650124 | 0.84 | HSP90AA1 (0.50) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3655641 | 0.84 | MAPK14 (0.44) | RAB9ANPC1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL3655153 | 0.84 | NPC1 (0.43) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3657580 | 0.84 | ESR1 (0.46) | RAB9AMAPTMEN1KMT2AKCNK3 | |
| SCHEMBL3652477 | 0.83 | ESR1 (0.45) | RAB9ANPC1MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL3652245 | 0.82 | NPC1 (0.39) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL3653109 | 0.82 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2MAPTGAA | |
| Trifluoroacetic Acid SCHEMBL3657556 | 0.80 | HSP90AA1 (0.45) | RAB9ANPC1SMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |