Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658319 | 0.85 | MEN1 (0.43) | MEN1KMT2ALMNAATML3MBTL1 | |
| SCHEMBL3653066 | 0.80 | KMT2A (0.48) | MEN1KMT2ALMNAATML3MBTL1 | |
| SCHEMBL3658581 | 0.77 | PLA2G4A (0.46) | MEN1KMT2AATML3MBTL1MDH1 | |
| SCHEMBL3657841 | 0.69 | PLA2G4A (0.50) | MEN1KMT2AATML3MBTL1MDH1 | |
| SCHEMBL2807365 | 0.69 | PLA2G4A (0.59) | — | |
| SCHEMBL3656549 | 0.68 | PLA2G4A (0.44) | — | |
| SCHEMBL23606009 | 0.68 | ALDH1A1 (0.59) | LMNAGRM4ALDH1A1PPARGPPARD | |
| SCHEMBL13127472 | 0.67 | PLA2G4A (0.46) | AKR1C3 | |
| SCHEMBL1782842 | 0.67 | LMNA (0.69) | MEN1KMT2ALMNATRPV1KDM4E | |
| SCHEMBL2806998 | 0.66 | AKR1C3 (0.39) | KMT2ALMNAAKR1C3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215059-A2 | NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVE, SUITABLE FOR INHIBITING PHOSPHOLIPASE A2 | Westfälische Wilhelms-Universität Münster (DE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009040314-A2 | NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVES, SUITABLE FOR INHIBITING PHOSPHOLIPASE A2 | Westfälische Wilhelms Universität Münster (DE) | 2009-04-02 | — | — | WO | disclosed |