Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.41 |
| ▸ | SMO | Q99835 | 9/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659346 | 0.90 | NR3C1 (0.38) | NR3C1SMOCYP11B1CYP11B2PGR | |
| SCHEMBL3656136 | 0.85 | SMO (0.35) | NR3C1SMOCYP11B1CYP11B2 | |
| SCHEMBL837594 | 0.73 | NR3C1 (0.51) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL1414583 | 0.68 | ADRA2C (0.31) | — | |
| SCHEMBL3658681 | 0.68 | MAPT (0.32) | — | |
| SCHEMBL1415502 | 0.67 | NR3C1 (0.48) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL3659001 | 0.65 | TDP1 (0.40) | — | |
| SCHEMBL3660501 | 0.65 | MAPT (0.32) | — | |
| SCHEMBL4282965 | 0.64 | NR3C1 (0.86) | NR3C1CYP11B1CYP11B2PGR | |
| SCHEMBL837940 | 0.64 | NR3C1 (0.51) | NR3C1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | claimed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | claimed |
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |