Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659266 | 0.88 | EEF2K (0.36) | HDAC6EEF2KMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3656187 | 0.76 | MAPT (0.36) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL837441 | 0.74 | KDM4E (0.36) | KDM4EALDH1A1MAPTEEF2KMEN1 | |
| SCHEMBL15469110 | 0.69 | MAPT (0.43) | KDM4EALDH1A1HDAC6MAPTKAT2B | |
| SCHEMBL3652084 | 0.67 | P2RX7 (0.33) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3660073 | 0.64 | MAPT (0.32) | ALDH1A1MAPT | |
| SCHEMBL838173 | 0.63 | EEF2K (0.38) | HDAC6EEF2KMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9609771 | 0.63 | KAT2B (0.43) | KDM4EALDH1A1MAPTKAT2BSMN1; SMN2 | |
| SCHEMBL16144682 | 0.62 | CASP3 (0.42) | KDM4EALDH1A1MEN1KMT2AKAT2B | |
| SCHEMBL10832271 | 0.61 | LMNA (0.53) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | claimed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | claimed |
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |