Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652084 | 0.83 | P2RX7 (0.33) | MAPTGAAALDH1A1LMNA | |
| SCHEMBL3656187 | 0.82 | MAPT (0.36) | MAPTLMNAHPGD | |
| SCHEMBL3660501 | 0.78 | MAPT (0.32) | MAPTGAAALDH1A1LMNAHPGD | |
| SCHEMBL838933 | 0.72 | AR (0.38) | MAPTGAAALDH1A1LMNAHPGD | |
| SCHEMBL3803786 | 0.68 | MRGPRX4 (0.37) | MAPTALDH1A1NPSR1 | |
| SCHEMBL3659266 | 0.65 | EEF2K (0.36) | — | |
| SCHEMBL3658823 | 0.64 | KDM4E (0.38) | MAPTALDH1A1 | |
| SCHEMBL3654236 | 0.64 | LOXL2 (0.37) | MAPTALDH1A1HPGD | |
| SCHEMBL3658596 | 0.63 | EIF4E (0.36) | — | |
| SCHEMBL3653089 | 0.62 | RECQL (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | claimed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | claimed |
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |