Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 3/20 | 0.38 |
| ▸ | FNTB | P49356 | 3/20 | 0.38 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365634 | 0.88 | CES1 (0.38) | CES1IDO1EGFRHTTKDM4E | |
| SCHEMBL365934 | 0.86 | KDM4E (0.45) | IDO1PTGS2FNTAFNTBEGFR | |
| SCHEMBL367090 | 0.85 | MAPT (0.44) | IDO1EGFRHTTKDM4EMEN1 | |
| SCHEMBL366810 | 0.83 | PTGS2 (0.45) | IDO1PTGS2FNTAFNTBEGFR | |
| SCHEMBL366875 | 0.82 | EGFR (0.42) | IDO1PTGS2FNTAFNTBEGFR | |
| SCHEMBL365999 | 0.81 | ALDH1A1 (0.48) | IDO1EGFRKDM4EMEN1APAF1 | |
| SCHEMBL364999 | 0.80 | ALDH1A1 (0.60) | CES1HTTKDM4EMEN1ALDH1A1 | |
| SCHEMBL366370 | 0.79 | EGFR (0.43) | IDO1PTGS2FNTAFNTBEGFR | |
| SCHEMBL367204 | 0.79 | RORC (0.43) | IDO1PTGS2FNTAFNTBEGFR | |
| SCHEMBL365912 | 0.78 | CES1 (0.45) | CES1IDO1PLA2G2DEGFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |