Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657680 | 0.94 | RAB9A (0.51) | RAB9ANPC1TP53ALOX15SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3657679 | 0.91 | RAB9A (0.46) | RAB9ANPC1TP53SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3654963 | 0.90 | — | — | |
| Trifluoroacetic Acid SCHEMBL3653624 | 0.89 | KDM4E (0.40) | TP53ALDH1A1MAPTMCL1 | |
| SCHEMBL3652812 | 0.84 | PDE4D (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL3653109 | 0.84 | RAB9A (0.45) | RAB9ANPC1TP53SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3652805 | 0.83 | KDM4E (0.41) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| Trifluoroacetic Acid SCHEMBL3657521 | 0.83 | MEN1 (0.42) | RAB9ANPC1TP53SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3659583 | 0.83 | PARP10 (0.34) | — | |
| Trifluoroacetic Acid SCHEMBL3655787 | 0.83 | MLYCD (0.46) | RAB9ANPC1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |