Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655137 | 0.86 | RAB9A (0.43) | MEN1KMT2AFUCA1ALDH1A1RECQL | |
| Trifluoroacetic Acid SCHEMBL3659677 | 0.85 | HRH3 (0.32) | HRH3 | |
| SCHEMBL3658726 | 0.82 | CYP1A2 (0.44) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3648675 | 0.82 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL3660320 | 0.81 | HRH3 (0.41) | HRH3MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3658188 | 0.80 | BCL9 (0.41) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3651913 | 0.80 | BCL9 (0.41) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3653649 | 0.80 | BCL9 (0.41) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3661317 | 0.79 | HRH3 (0.43) | HRH3MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1729647 | 0.79 | EPHX2 (0.38) | HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |