Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.72 |
| ▸ | FEN1 | P39748 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.49 |
| ▸ | WNT3A | P56704 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8735550 | 0.89 | ERCC5 (0.74) | ERCC5FEN1HPGDSMN1; SMN2GAA | |
| SCHEMBL269381 | 0.84 | ERCC5 (0.68) | ERCC5FEN1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL29483365 | 0.84 | ERCC5 (0.68) | ERCC5FEN1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL8383887 | 0.83 | ERCC5 (0.67) | ERCC5FEN1HPGDSMN1; SMN2GAA | |
| SCHEMBL828846 | 0.82 | KMT2A (0.62) | ERCC5FEN1SMN1; SMN2GAAKMT2A | |
| SCHEMBL29541385 | 0.82 | KMT2A (0.62) | ERCC5FEN1SMN1; SMN2GAAKMT2A | |
| SCHEMBL17867035 | 0.82 | ERCC5 (0.65) | ERCC5FEN1HPGDSMN1; SMN2GAA | |
| SCHEMBL30089517 | 0.80 | CTNNB1 (0.68) | ERCC5FEN1HPGDL3MBTL1KMT2A | |
| SCHEMBL15979740 | 0.80 | CTNNB1 (0.68) | ERCC5FEN1HPGDL3MBTL1KMT2A | |
| SCHEMBL3381401 | 0.80 | MAOA (0.56) | ERCC5FEN1HPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103376648-B | Photosensitive resin composition, black matrix, color filter and liquid crystal display element | CHI MEI CORP. (CN) | 2016-03-30 | — | — | CN | disclosed |
| US-8399483-B2 | Quinoxaline and quinoline derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2013-03-19 | — | — | US | disclosed |
| EP-2231641-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009081105-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-07-02 | — | — | WO | disclosed |
| US-7399760-B2 | 1-(4-Methylsulfanyl-phenyl)-6-phenyl-pyrimidin-2,4-(1H)-dione;cyclooxygenase and prostaglandin inhibitor; tumor necrosis factor and interleukins 1, 6, 8, 12 antagonist; | BEXEL PHARMACEUTICALS INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-20060194799-A1 | Novel pyrimidinedione derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2006-08-31 | — | — | US | disclosed |
| US-20060111369-A1 | Synthesis, characterization and biological action of optically active isomers of floxacins | SOMBERG JOHN C | 2006-05-25 | — | — | US | disclosed |
| WO-2006052264-A2 | SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTION OF OPTICALLY ACTIVE ISOMERS OF FLOXACINS | SOMBERG JOHN CHARIN (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20040009975-A1 | Novel pyrimidinedione derivatives | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2004-01-15 | — | — | US | disclosed |
| WO-2003084937-A2 | PYRIMIDINEDIONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOLOGICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-10-16 | — | — | WO | disclosed |
| US-4593118-A | 2-amido-3-aminocarboxylic acid esters and process of preparation thereof | ETHYL CORPORATION (US) | 1986-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009975-A1 | Novel pyrimidinedione derivatives | TYMS, DPYD, TYMP | ERCC5 852/4885FEN1 1157/4885HPGD 228/4885 |
| US-20060111369-A1 | Synthesis, characterization and biological action of optically active isomers of floxacins | TNNI3, TNNC1, TNNT2 | ERCC5 4282/4885FEN1 865/4885HPGD 1481/4885 |
| US-20060194799-A1 | Novel pyrimidinedione derivatives | TYMS, TYMP, DPYD | ERCC5 850/4885FEN1 1600/4885HPGD 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.