Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365225 | 0.91 | CA12 (0.35) | POLBMAPTTP53MEN1KMT2A | |
| SCHEMBL367759 | 0.87 | STS (0.41) | MKNK2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL367244 | 0.87 | KDM4E (0.33) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL366019 | 0.79 | STS (0.41) | MAPTMEN1KMT2ANPC1GAA | |
| SCHEMBL367236 | 0.77 | TSHR (0.47) | POLBTP53MEN1KMT2ANPC1 | |
| SCHEMBL367389 | 0.77 | IDO1 (0.36) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL365489 | 0.77 | KMT2A (0.36) | MKNK2MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL365191 | 0.77 | MKNK2 (0.40) | MKNK2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL367765 | 0.77 | NPC1 (0.43) | MKNK2MAPTNPC1GAAATM | |
| SCHEMBL366075 | 0.76 | MAPT (0.35) | POLBMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |