Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365272 | 0.93 | CA12 (0.42) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL367749 | 0.93 | NPC1 (0.41) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365020 | 0.93 | BAZ2B (0.43) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL366817 | 0.89 | NPC1 (0.39) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365191 | 0.87 | MKNK2 (0.40) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365175 | 0.83 | NPC1 (0.43) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL367759 | 0.82 | STS (0.41) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL367221 | 0.81 | BAZ2B (0.42) | KDM4EALDH1A1MAPTBAZ2BBAZ2A | |
| SCHEMBL366558 | 0.81 | NPC1 (0.42) | NPC1GAAATMRXFP1KDM4E | |
| SCHEMBL365489 | 0.80 | KMT2A (0.36) | ALDH1A1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |