Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 3/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660207 | 0.91 | F2 (0.39) | MEN1KMT2AF2DRD2DRD3 | |
| SCHEMBL3405538 | 0.91 | CTSD (0.39) | MEN1MAPTKMT2ACTSDBACE1 | |
| SCHEMBL3406626 | 0.90 | CTSD (0.39) | MEN1MAPTKMT2ACTSDBACE1 | |
| SCHEMBL3406082 | 0.89 | MEN1 (0.38) | MEN1MAPTKMT2ACTSDBACE1 | |
| SCHEMBL975805 | 0.89 | CACNA2D1 (0.38) | MEN1MAPTKMT2ACTSDBACE1 | |
| SCHEMBL3653841 | 0.89 | F2 (0.37) | F2LMNATP53PRMT5P2RX7 | |
| SCHEMBL3661828 | 0.89 | F2 (0.37) | BACE1F2LMNATP53PRMT5 | |
| SCHEMBL3406386 | 0.88 | MEN1 (0.37) | MEN1MAPTKMT2ACTSDBACE1 | |
| SCHEMBL977615 | 0.87 | ALOX5 (0.39) | MEN1MAPTKMT2ACTSDBACE1 | |
| SCHEMBL3408675 | 0.86 | DRD2 (0.40) | MEN1MAPTKMT2ACTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234966-A2 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | Sanofi-Aventis (FR) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009106708-A2 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI-AVENTIS (FR) | 2009-09-03 | — | — | WO | disclosed |