Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6519318 | 0.99 | DRD2 (0.39) | DRD2DRD3HSD17B10CNR1CNR2 | |
| SCHEMBL3406225 | 0.91 | SCN9A (0.41) | DRD2DRD3ALOX5EPHX2KDM4E | |
| SCHEMBL977615 | 0.91 | ALOX5 (0.39) | DRD2DRD3F2CACNA2D1CACNA1B | |
| SCHEMBL3661726 | 0.90 | CCR2 (0.39) | DRD2DRD3F2CACNA2D1CACNA1B | |
| SCHEMBL979308 | 0.89 | CACNA2D1 (0.41) | DRD2DRD3F2CACNA2D1CACNA1B | |
| SCHEMBL3406082 | 0.89 | MEN1 (0.38) | DRD2DRD3F2CACNA2D1CACNA1B | |
| SCHEMBL3405538 | 0.89 | CTSD (0.39) | DRD2DRD3HSD17B10F2CACNA2D1 | |
| SCHEMBL975805 | 0.89 | CACNA2D1 (0.38) | DRD2DRD3F2CACNA2D1CACNA1B | |
| SCHEMBL1989675 | 0.88 | NPC1 (0.37) | DRD2DRD3CNR1CNR2F2 | |
| SCHEMBL3408730 | 0.88 | DDR1 (0.36) | DRD2DRD3F2CACNA2D1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254862-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009118473-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2009-10-01 | — | — | WO | disclosed |