Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 11/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661420 | 0.87 | CDK2 (0.44) | CDC7CDK2GSK3BROCK2MAP4K4 | |
| SCHEMBL3656027 | 0.84 | CDC7 (0.50) | CDC7CDK2GSK3BROCK2MAP4K4 | |
| SCHEMBL3723065 | 0.77 | MKNK1 (0.49) | ROCK2MKNK1MKNK2POLB | |
| SCHEMBL14303253 | 0.73 | POLB (0.48) | POLB | |
| SCHEMBL3664819 | 0.73 | KMO (0.59) | CDC7CDK2GSK3BROCK2MAP4K4 | |
| SCHEMBL3044785 | 0.70 | KMO (0.55) | CDK2GSK3BCLK4CCNT1CCNA2 | |
| SCHEMBL3656028 | 0.67 | ROCK2 (0.60) | CDK2ROCK2CCNT1CCNA2CDK9 | |
| SCHEMBL3713494 | 0.67 | CDK2 (0.39) | CDC7CDK2GSK3BROCK2MAP4K4 | |
| SCHEMBL18823359 | 0.67 | MEN1 (0.56) | ROCK2MAP4K4CAMKK2KMO | |
| SCHEMBL11002248 | 0.66 | CDC7 (0.52) | CDC7CDK2GSK3BROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |