Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813838 | 0.77 | SLC2A1 (0.43) | ROCK1KDM4EGAATDP1NPC1 | |
| SCHEMBL3715554 | 0.77 | PIM1 (0.46) | CDK2AURKACHUKPDPK1RPS6KB1 | |
| SCHEMBL3720566 | 0.72 | KMO (0.43) | CDK2AURKACHUKPDPK1RPS6KB1 | |
| SCHEMBL3661420 | 0.69 | CDK2 (0.44) | CDK2AURKACHUKPDPK1RPS6KB1 | |
| SCHEMBL8749753 | 0.69 | RAB9A (0.54) | KDM4EGAATDP1NPC1RAB9A | |
| SCHEMBL3661410 | 0.67 | CDC7 (0.50) | CDK2CDC7DBF4ROCK2MAP4K4 | |
| SCHEMBL3717171 | 0.65 | ROCK2 (0.41) | ROCK1ROCK2GSK3BPRKACA | |
| SCHEMBL3722649 | 0.64 | HTR7 (0.43) | CDK2AURKACHUKPDPK1RPS6KB1 | |
| SCHEMBL25305396 | 0.64 | CDC7 (0.50) | AURKASYKCDC7DBF4KDM4E | |
| SCHEMBL5564786 | 0.62 | ROCK1 (0.63) | AURKAROCK1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |