Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661410 | 0.87 | CDC7 (0.50) | CDK2KMOPOLBCAMKK2ROCK2 | |
| SCHEMBL3656028 | 0.79 | ROCK2 (0.60) | CDK2PDPK1AURKACHUKRPS6KB1 | |
| SCHEMBL3723069 | 0.77 | ROCK2 (0.65) | ROCK1MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL2368605 | 0.74 | ALDH1A1 (0.47) | MEN1ALDH1A1MAPK1KMT2AKDM4E | |
| SCHEMBL1987965 | 0.72 | MEN1 (0.48) | MEN1ALDH1A1MAPK1KMT2AKDM4E | |
| SCHEMBL3656027 | 0.71 | CDC7 (0.50) | CDK2KMOCAMKK2ROCK2CDC7 | |
| SCHEMBL3044785 | 0.69 | KMO (0.55) | CDK2PDPK1AURKACHUKRPS6KB1 | |
| SCHEMBL3713494 | 0.69 | CDK2 (0.39) | CDK2PDPK1AURKACHUKRPS6KB1 | |
| SCHEMBL3720566 | 0.67 | KMO (0.43) | CDK2PDPK1AURKACHUKRPS6KB1 | |
| SCHEMBL3664825 | 0.67 | KMO (0.57) | CDK2PDPK1KMOHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |