Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313712 | 0.76 | PIK3CD (0.49) | PIK3CDSMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4178662 | 0.72 | PIK3CD (0.47) | PIK3CDSMN1; SMN2APEX1MAPTMAPK8 | |
| SCHEMBL14047548 | 0.72 | PIK3CD (0.45) | PIK3CDSMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL19413117 | 0.70 | DHODH (0.46) | PIK3CDTP53 | |
| SCHEMBL1880602 | 0.68 | DHODH (0.46) | PIK3CDCYP1A2CYP3A4TP53MEN1 | |
| SCHEMBL716341 | 0.66 | L3MBTL1 (0.50) | PIK3CDSMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL29554697 | 0.66 | DHODH (0.50) | CYP1A2CYP2C19LMNATP53MEN1 | |
| SCHEMBL1313748 | 0.66 | PNMT (0.42) | PIK3CDSMN1; SMN2CYP3A4LMNA | |
| SCHEMBL4177662 | 0.65 | BDKRB1 (0.43) | PIK3CDLMNAMEN1KMT2A | |
| SCHEMBL17813592 | 0.64 | LMNA (0.50) | SMN1; SMN2APEX1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139882-A1 | 3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE ( PI3K) INHIBITORS | Amgen Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118455-A1 | δ3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE ( PI3K) INHIBITORS | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |