Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 4/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.42 |
| ▸ | MERTK | Q12866 | 7/20 | 0.42 |
| ▸ | FLT3 | P36888 | 6/20 | 0.42 |
| ▸ | GAS6 | Q14393 | 6/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185251 | 0.86 | GPR39 (0.44) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL3665002 | 0.84 | GPR39 (0.47) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL3664859 | 0.80 | GPR39 (0.51) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL3663909 | 0.80 | GPR39 (0.54) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL3663705 | 0.79 | GPR39 (0.43) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL4192009 | 0.79 | GPR39 (0.43) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL3662150 | 0.79 | DYRK1A (0.41) | GPR39TYRO3MERTKGRM5AXL | |
| SCHEMBL3720880 | 0.78 | GPR39 (0.38) | GPR39TYRO3MERTKFLT3GAS6 | |
| SCHEMBL4175691 | 0.78 | CYP1A2 (0.46) | GPR39GRM5ADORA2BADORA1CCNT1 | |
| SCHEMBL3714748 | 0.76 | TGFBR1 (0.46) | GPR39 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-02 | — | — | EP | disclosed |
| US-8343966-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-01-01 | — | — | US | disclosed |
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| US-20090215776-A1 | Organic compounds | ADCOCK CLAIRE | 2009-08-27 | — | — | US | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215776-A1 | Organic compounds | REN, RXFP1, MYLK | GPR39 222/4885TYRO3 3492/4885MERTK 4434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.