Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 2/20 | 0.39 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662984 | 0.88 | ALDH1A1 (0.42) | MAPTL3MBTL1POLBGAAALDH1A1 | |
| SCHEMBL3656520 | 0.87 | ALOX5 (0.38) | HTTMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2776545 | 0.82 | TARBP2 (0.54) | TARBP2PDCD4HTTMAPTNPC1 | |
| SCHEMBL2775303 | 0.82 | USP2 (0.48) | HTTMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL2775301 | 0.82 | USP2 (0.48) | HTTMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL2776676 | 0.72 | KMT2A (0.44) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2776674 | 0.72 | KMT2A (0.44) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2776072 | 0.71 | KDM4E (0.52) | MAPTNPC1RAB9AL3MBTL1GAA | |
| SCHEMBL28805031 | 0.70 | PTGS2 (0.53) | MAPTALDH1A1PTGS2PTGS1PDE3A | |
| SCHEMBL2778006 | 0.70 | KMT2A (0.42) | HTTMAPTL3MBTL1ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |