Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656520 | 0.90 | ALOX5 (0.38) | ALDH1A1MAPK1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL3661795 | 0.88 | TARBP2 (0.39) | ALDH1A1POLBKDM4EHPGDMAPT | |
| SCHEMBL2777213 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL2778520 | 0.81 | ADORA3 (0.55) | ALDH1A1MAPK1TSHRPOLBALOX15 | |
| SCHEMBL2777208 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL2778006 | 0.72 | KMT2A (0.42) | ALDH1A1TSHRNPSR1SMN1; SMN2LMNA | |
| SCHEMBL2778007 | 0.72 | KMT2A (0.42) | ALDH1A1TSHRNPSR1SMN1; SMN2LMNA | |
| SCHEMBL2776676 | 0.72 | KMT2A (0.44) | ALDH1A1MAPK1CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2776674 | 0.72 | KMT2A (0.44) | ALDH1A1MAPK1CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2776072 | 0.70 | KDM4E (0.52) | ALDH1A1MAPK1CACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |