Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TPH1 | P17752 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493835 | 0.81 | HTT (0.69) | MAPTHTTTPH1KDM4EMEN1 | |
| SCHEMBL3667161 | 0.78 | ALDH1A1 (0.59) | MAPTHTTKDM4EMEN1KMT2A | |
| SCHEMBL4083201 | 0.77 | NR1H4 (0.52) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3666056 | 0.76 | KDM4E (0.54) | MAPTHTTKDM4EKMT2AALDH1A1 | |
| SCHEMBL1660913 | 0.76 | SMN1; SMN2 (0.82) | MAPTHTTKDM4EMEN1KMT2A | |
| SCHEMBL14363621 | 0.74 | HTT (0.68) | MAPTHTTKDM4EMEN1KMT2A | |
| SCHEMBL20116413 | 0.74 | SMN1; SMN2 (0.65) | MAPTHTTKDM4EMEN1KMT2A | |
| SCHEMBL60781 | 0.74 | SMN1; SMN2 (0.69) | MAPTHTTTPH1KDM4EMEN1 | |
| SCHEMBL3665206 | 0.74 | DPP4 (0.43) | MEN1KMT2ANPC1TSHRRAB9A | |
| SCHEMBL493438 | 0.73 | KMT2A (0.67) | MAPTHTTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |