Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493923 | 0.88 | KMT2A (0.65) | KMT2APOLBKDM4EMAPTHTT | |
| SCHEMBL493835 | 0.82 | HTT (0.69) | KMT2APOLBKDM4EMAPTHTT | |
| SCHEMBL493192 | 0.81 | NPC1 (0.56) | KMT2APOLBKDM4EMAPTHTT | |
| SCHEMBL493052 | 0.79 | KDM4E (0.73) | KMT2AKDM4EMAPT | |
| SCHEMBL494360 | 0.79 | TSHR (0.53) | KMT2AKDM4EMAPT | |
| SCHEMBL493603 | 0.77 | KMT2A (0.44) | KMT2APOLBKDM4EMAPT | |
| SCHEMBL494155 | 0.77 | SMN1; SMN2 (0.69) | KMT2AKDM4EMAPT | |
| SCHEMBL8178988 | 0.76 | PDE4A (0.71) | KMT2APOLBKDM4EMAPTHTT | |
| SCHEMBL493401 | 0.74 | ALDH1A1 (0.42) | KMT2APOLB | |
| SCHEMBL20116932 | 0.74 | KMT2A (0.71) | KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | KMT2A 1749/4885POLB 2120/4885KDM4E 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.