Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664746 | 0.86 | HDAC4 (0.49) | SMN1; SMN2LMNAHDAC1HDAC6S1PR1 | |
| SCHEMBL4083201 | 0.82 | NR1H4 (0.52) | GAARAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL493495 | 0.78 | KDM4E (0.70) | KDM4EGAARAB9ATP53SMN1; SMN2 | |
| SCHEMBL3661963 | 0.76 | MAPT (0.59) | KDM4ERAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL12171106 | 0.75 | RAB9A (0.67) | KDM4EGAARAB9ATP53SMN1; SMN2 | |
| SCHEMBL3665206 | 0.72 | DPP4 (0.43) | RAB9ANPC1TSHRL3MBTL1S1PR1 | |
| SCHEMBL417374 | 0.72 | NPC1 (0.61) | KDM4EGAARAB9ATP53SMN1; SMN2 | |
| SCHEMBL28637876 | 0.71 | NPC1 (0.74) | KDM4ERAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL8830004 | 0.70 | NPC1 (0.59) | KDM4EGAARAB9ATP53SMN1; SMN2 | |
| SCHEMBL27792725 | 0.70 | NR1H4 (0.49) | GAARAB9ATP53SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |