Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087777 | 0.92 | CYP3A4 (0.91) | CYP3A4SMN1; SMN2TSHRTP53LMNA | |
| SCHEMBL232779 | 0.90 | TP53 (0.64) | CYP3A4SMN1; SMN2TSHRTP53TDP1 | |
| Methane SCHEMBL7896214 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TSHRTP53TDP1 | |
| SCHEMBL28172063 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TSHRTP53TDP1 | |
| SCHEMBL28117879 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TSHRTP53TDP1 | |
| SCHEMBL9133420 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TSHRTP53TDP1 | |
| Hydrochloric Acid SCHEMBL2299193 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TSHRTP53TDP1 | |
| SCHEMBL8060267 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TP53TDP1LMNA | |
| Nitromide SCHEMBL193674 | 0.88 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TSHRTP53LMNA | |
| Hydrochloric Acid SCHEMBL3088495 | 0.88 | TP53 (0.62) | CYP3A4SMN1; SMN2TSHRTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680334-B2 | Process for the preparation of iosimenol | MALLINCKRODT LLC (US) | 2014-03-25 | — | — | US | disclosed |
| US-20130261338-A1 | Process for the Preparation of Iosimenol | MALLINCKRODT LLC (US) | 2013-10-03 | — | — | US | disclosed |
| US-8445725-B2 | Process for the preparation of iosimenol | MALLINCKRODT LLC (US) | 2013-05-21 | — | — | US | disclosed |
| EP-2240432-B1 | PROCESS FOR THE PREPARATION OF IOSIMENOL | MALLINCKRODT LLC (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20100280270-A1 | Process for the Prepartion of Iosimenol | MNK 2011 LLC (F/K/A MALLINCKRODT INC.) | 2010-11-04 | — | — | US | disclosed |
| EP-2240432-A1 | PROCESS FOR THE PREPARATION OF IOSIMENOL | Mallinckrodt Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009091758-A1 | PROCESS FOR THE PREPARATION OF IOSIMENOL | MALLINCKRODT INC. (US) | 2009-07-23 | — | — | WO | disclosed |
| EP-1186305-A1 | New brominated compounds as contrast media for X-ray mammography | Schering Aktiengesellschaft (DE) | 2002-03-13 | — | — | EP | disclosed |
| US-4138589-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS USED AS X-RAY CONTRAST AGENTS | MALLINCKRODT, INC. (US) | 1979-02-06 | — | — | US | disclosed |
| US-4069250-A | X-RAY CONTRAST AGENTS | MALLINCKRODT, INC. (US) | 1978-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280270-A1 | Process for the Prepartion of Iosimenol | DHCR24, DRD4, NONO | CYP3A4 445/4885SMN1; SMN2 2056/4885TSHR 1558/4885 |
| US-20130261338-A1 | Process for the Preparation of Iosimenol | ITPR3, ITPR2, DHCR24 | CYP3A4 483/4885SMN1; SMN2 2074/4885TSHR 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.