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ITPR2

Inositol 1,4,5-trisphosphate-gated calcium ch · Q14571 · ITPR2 on Sugi Atlas →

959 patent compounds predicted against ITPR2, 571 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL7433563 SCHEMBL7433563 0.69 5/20
SCHEMBL8690883 SCHEMBL8690883 0.53 5/20
SCHEMBL8691271 SCHEMBL8691271 0.53 5/20
Phytic Acid Phytic Acid (SCHEMBL1172887) 0.52 5/20
SCHEMBL142299 SCHEMBL142299 0.43 5/20
SCHEMBL8815585 SCHEMBL8815585 0.43 5/20
SCHEMBL4348223 SCHEMBL4348223 0.41 5/20
Ins(1,4,5)P3 Ins(1,4,5)P3 (SCHEMBL98182) 1.00 4/20
SCHEMBL282194 SCHEMBL282194 1.00 4/20
Ins(1,4,5)P3 Ins(1,4,5)P3 (SCHEMBL381458) 1.00 4/20
SCHEMBL382752 SCHEMBL382752 1.00 4/20
Ins(1,4,5)P3 Ins(1,4,5)P3 (SCHEMBL382820) 1.00 4/20
SCHEMBL405897 SCHEMBL405897 1.00 4/20
SCHEMBL2044892 SCHEMBL2044892 1.00 4/20
SCHEMBL2044896 SCHEMBL2044896 1.00 4/20
SCHEMBL2510044 SCHEMBL2510044 1.00 4/20
SCHEMBL2905564 SCHEMBL2905564 1.00 4/20
Ins(1,4,5)P3 Ins(1,4,5)P3 (SCHEMBL4321735) 1.00 4/20
Ins(1,4,5)P3 Ins(1,4,5)P3 (SCHEMBL4871682) 1.00 4/20
Ins(1,4,5)P3 Ins(1,4,5)P3 (SCHEMBL4874594) 1.00 4/20

Clinical trials — most relevant to ITPR2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Magnesium Administration in Liver Transplantation and Reperfusion Injury PHASE4COMPLETED
The Effect of Protein on Calcium Absorption and Gastric Acid Production PHASE4COMPLETED
Effect of PRP Injection After Arthroscopic Meniscal Repair in the Healing Process PHASE4COMPLETED
Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial PHASE2/PHASE3UNKNOWN
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility? PHASE2/PHASE3UNKNOWN
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome PHASE1/PHASE2NOT_YET_RECRUITING
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Calcium Channel Blockade in Primary Aldosteronism PHASE2COMPLETED
Bioequivalence Study of Tacrolimus in Healthy Volunteers PHASE1COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A EARLY_PHASE1COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors nanUNKNOWN
The Energetic Origin of Neurodegeneration in MS nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers nanCOMPLETED
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development nanRECRUITING
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity. nanUNKNOWN
Molecular Markers of Human Sperm Function nanWITHDRAWN
Evaluation of A Clinical Diagnostic Test for CRDS nanRECRUITING
Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia nanUNKNOWN
Oxidative Stress in Women Treated With Atosiban for Impending Preterm Birth nanCOMPLETED
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY) nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
Genomic Landscape of Intramedullary Astrocytoma nanUNKNOWN
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia nanUNKNOWN
Identifying Genetic Causes of IC/BPS nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a ITPR2 binder may also engage these)

ProteinNameSimilarity
P29994 — 1.000 P29994 →
ITPR3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 1.000 landscape →
Q8WN96 — 1.000 Q8WN96 →
Q9Z329 — 1.000 Q9Z329 →
Q9TU34 — 1.000 Q9TU34 →
P11881 — 1.000 P11881 →
ITPR1 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 1.000 landscape →
P29995 — 1.000 P29995 →
Q8WN95 — 1.000 Q8WN95 →
P70227 — 1.000 P70227 →
Q8WSR4 — 0.999 Q8WSR4 →
Q63269 — 0.995 Q63269 →
P29993 — 0.988 P29993 →
DNAJC13 DnaJ homolog subfamily C member 13 0.987 landscape →
Q24498 — 0.987 Q24498 →
Q5R6J0 — 0.981 Q5R6J0 →
PDS5A Sister chromatid cohesion protein PDS5 homolog A 0.979 landscape →
Q6A026 — 0.979 Q6A026 →
O94915 — 0.979 O94915 →
O35099 — 0.979 O35099 →
B1AY13 — 0.979 B1AY13 →
ECPAS Proteasome adapter and scaffold protein ECM29 0.978 landscape →
A1L1F4 — 0.978 A1L1F4 →
P97878 — 0.978 P97878 →
USP24 Ubiquitin carboxyl-terminal hydrolase 24 0.978 landscape →
RYR2 Ryanodine receptor 2 0.978 landscape →
Q0E908 — 0.977 Q0E908 →
Q5F3U9 — 0.977 Q5F3U9 →
Q9D4H1 — 0.977 Q9D4H1 →
MAP3K5 Mitogen-activated protein kinase kinase kinase 5 0.977 landscape →