Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.47 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899168 | 1.00 | HRH1 (0.58) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8987516 | 0.98 | HRH1 (0.56) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| SCHEMBL28490534 | 0.83 | HRH1 (0.58) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| SCHEMBL9787802 | 0.82 | GABBR2 (0.61) | HRH1HTR2AGABBR2GABBR1TAAR1 | |
| SCHEMBL4789777 | 0.82 | GABBR2 (0.61) | HRH1HTR2AGABBR2GABBR1TAAR1 | |
| SCHEMBL1507699 | 0.82 | TRPA1 (0.48) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| SCHEMBL9137323 | 0.82 | HRH1 (0.62) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| SCHEMBL8274952 | 0.82 | TRPA1 (0.48) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| SCHEMBL1546696 | 0.82 | TRPA1 (0.48) | HRH1HTR2AGABBR2GABBR1ALDH1A1 | |
| SCHEMBL1986953 | 0.82 | GABBR2 (0.61) | HRH1HTR2AGABBR2GABBR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104640894-B | two-component polyurethane composition | SIKA技术股份公司 | 2018-11-13 | — | — | CN | claimed |
| EP-2225298-A1 | CURABLE COMPOSITIONS HAVING LESS VOLATILIZATION | Sika Technology AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009080738-A1 | CURABLE COMPOSITIONS HAVING LESS VOLATILIZATION | SIKA TECHNOLOGY AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| EP-0982026-B1 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | EP | disclosed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |