SCHEMBL7899168

SCHEMBL7899168

NCC[C@H](CO)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.58
HTR2A P28223 2/20 0.48
GABBR2 O75899 2/20 0.47
GABBR1 Q9UBS5 2/20 0.47
ALDH1A1 P00352 1/20 0.45
TAAR1 Q96RJ0 4/20 0.44
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
PKM P14618 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
TSHR P16473 1/20 0.41
CYP2C19 P33261 1/20 0.41
TRPA1 O75762 2/20 0.39
SLC6A2 P23975 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3662680 1.00 HRH1 (0.58) HRH1HTR2AGABBR2GABBR1ALDH1A1
Hydrochloric Acid SCHEMBL8987516 0.98 HRH1 (0.56) HRH1HTR2AGABBR2GABBR1ALDH1A1
SCHEMBL28490534 0.83 HRH1 (0.58) HRH1HTR2AGABBR2GABBR1ALDH1A1
SCHEMBL9787802 0.82 GABBR2 (0.61) HRH1HTR2AGABBR2GABBR1TAAR1
SCHEMBL4789777 0.82 GABBR2 (0.61) HRH1HTR2AGABBR2GABBR1TAAR1
SCHEMBL1507699 0.82 TRPA1 (0.48) HRH1HTR2AGABBR2GABBR1ALDH1A1
SCHEMBL9137323 0.82 HRH1 (0.62) HRH1HTR2AGABBR2GABBR1ALDH1A1
SCHEMBL8274952 0.82 TRPA1 (0.48) HRH1HTR2AGABBR2GABBR1ALDH1A1
SCHEMBL1546696 0.82 TRPA1 (0.48) HRH1HTR2AGABBR2GABBR1ALDH1A1
SCHEMBL1986953 0.82 GABBR2 (0.61) HRH1HTR2AGABBR2GABBR1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184236-B1 Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative HOFFMANN-LA ROCHE INC. 2001-02-06 US disclosed