Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661611 | 0.82 | MTNR1A (0.44) | SMN1; SMN2KMT2AMTNR1AMTNR1B | |
| SCHEMBL12312065 | 0.81 | DRD2 (0.43) | MTNR1AMTNR1B | |
| SCHEMBL25236544 | 0.76 | HTR2A (0.55) | SMN1; SMN2KMT2A | |
| SCHEMBL16935807 | 0.75 | CA12 (0.61) | SMN1; SMN2LMNAALDH1A1KMT2AHTT | |
| SCHEMBL31664344 | 0.71 | KMT2A (0.53) | SMN1; SMN2LMNAALDH1A1KMT2AGLA | |
| SCHEMBL29037917 | 0.70 | GLA (0.72) | SMN1; SMN2LMNAALDH1A1KMT2AGLA | |
| SCHEMBL17229314 | 0.70 | HTR2A (0.37) | — | |
| SCHEMBL17253669 | 0.68 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1GLAKDM4E | |
| SCHEMBL1159713 | 0.68 | KMT2A (0.63) | SMN1; SMN2ALDH1A1KMT2AGLAMEN1 | |
| SCHEMBL3661730 | 0.67 | TAAR1 (0.46) | LMNAKMT2AGLATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222671-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | Glaxo Group Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009080728-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |