Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | APOL1 | O14791 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628640 | 0.81 | PTGS1 (0.34) | — | |
| SCHEMBL29514811 | 0.81 | PTGS1 (0.34) | — | |
| SCHEMBL29242847 | 0.80 | MAOA (0.33) | KDM4EALDH1A1HPGD | |
| SCHEMBL29242849 | 0.78 | TSHR (0.32) | KDM4EALDH1A1HPGD | |
| SCHEMBL29242848 | 0.74 | PSEN1 (0.38) | KDM4EALDH1A1 | |
| SCHEMBL6769792 | 0.73 | CAPN1 (0.39) | — | |
| SCHEMBL569538 | 0.73 | KDM4E (0.38) | KDM4EALDH1A1GAAHPGDHIF1A | |
| SCHEMBL10705687 | 0.71 | — | — | |
| SCHEMBL29242855 | 0.68 | PSEN1 (0.34) | ALDH1A1 | |
| SCHEMBL2142826 | 0.67 | PSEN1 (0.34) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220030-A2 | 4- (P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | Edison Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009061744-A2 | 4- (P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | EDISON PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |