Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56335 | 0.85 | CA2 (0.48) | ALDH1A1GAAHPGDACHEMAPK1 | |
| SCHEMBL16956005 | 0.82 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2MAPTGAAHPGD | |
| SCHEMBL14658523 | 0.82 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTGAAHPGD | |
| SCHEMBL524383 | 0.82 | AR (0.55) | ALDH1A1SMN1; SMN2MAPTGAAHPGD | |
| SCHEMBL16335953 | 0.80 | TSHR (0.39) | ALDH1A1SMN1; SMN2MAPTGAAHPGD | |
| SCHEMBL11334799 | 0.78 | GAA (0.40) | ALDH1A1SMN1; SMN2MAPTGAAHPGD | |
| SCHEMBL11673151 | 0.77 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDACHEMAPK1 | |
| SCHEMBL9320075 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MAPTGAATHRBTSHR | |
| SCHEMBL9350206 | 0.76 | RXRA (0.35) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL5027104 | 0.75 | PDE4B (0.40) | ALDH1A1SMN1; SMN2MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222668-A1 | TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | Arena Pharmaceuticals, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009078983-A1 | TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2009-06-25 | — | — | WO | disclosed |