Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | RAC1 | P63000 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659800 | 0.80 | MEN1 (0.34) | KDM4EMEN1KMT2APOLBGAA | |
| SCHEMBL13929789 | 0.79 | PLAU (0.45) | LRRK2MAPT | |
| SCHEMBL996497 | 0.78 | CCR1 (0.42) | LRRK2MEN1KMT2AGAANPC1 | |
| SCHEMBL3657864 | 0.78 | HTR2A (0.37) | KDM4EMEN1KMT2APOLBGAA | |
| SCHEMBL3627208 | 0.77 | TDO2 (0.51) | KDM4EMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3625396 | 0.77 | HTT (0.36) | KDM4EMEN1KMT2AGAAESR1 | |
| SCHEMBL3624833 | 0.77 | ENPP3 (0.43) | KDM4EMEN1KMT2APOLBGAA | |
| SCHEMBL15216114 | 0.76 | GAA (0.38) | KDM4EMEN1KMT2APOLBGAA | |
| SCHEMBL8083922 | 0.76 | PTGS2 (0.39) | KDM4ENPC1MAPTRAB9A | |
| SCHEMBL997481 | 0.74 | ADORA2A (0.33) | MEN1KMT2APOLBGAAGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033466-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE | PHENOMIX CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |