Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | BMP1 | P13497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778352 | 0.88 | PLK1 (0.39) | PLK1 | |
| SCHEMBL2775492 | 0.82 | ALDH1A1 (0.38) | DRD2HTR2AMMP2BMP1 | |
| SCHEMBL3662121 | 0.69 | TSHR (0.34) | DRD2HTR2AMMP2BMP1 | |
| SCHEMBL3662123 | 0.69 | TSHR (0.34) | DRD2HTR2AMMP2BMP1 | |
| SCHEMBL3532745 | 0.66 | NPC1 (0.40) | PLK1 | |
| SCHEMBL6853026 | 0.66 | LMNA (0.40) | — | |
| SCHEMBL285668 | 0.66 | L3MBTL1 (0.44) | — | |
| SCHEMBL285476 | 0.64 | L3MBTL1 (0.45) | — | |
| SCHEMBL30999039 | 0.64 | HTT (0.39) | — | |
| SCHEMBL19900847 | 0.64 | ADORA3 (0.39) | MMP2BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |