Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2468483 | 0.91 | NPC1 (0.71) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL1667825 | 0.85 | RAB9A (0.73) | ALDH1A1TSHRNPC1GRM5SMN1; SMN2 | |
| SCHEMBL6455626 | 0.84 | SMYD3 (0.69) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL6455623 | 0.84 | SMYD3 (0.69) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL11241115 | 0.84 | RAB9A (0.75) | ALDH1A1TSHRNPC1GRM5SMN1; SMN2 | |
| SCHEMBL30098987 | 0.82 | ALDH1A1 (0.63) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL1711687 | 0.82 | ALDH1A1 (0.63) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL29530916 | 0.82 | ALDH1A1 (0.63) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL30938355 | 0.81 | MCHR1 (0.51) | ALDH1A1TSHRMCHR1NPC1GRM5 | |
| SCHEMBL4516387 | 0.81 | ALDH1A1 (0.72) | ALDH1A1TSHRMCHR1NPC1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |