Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.37 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733710 | 0.78 | BCL2L1 (0.43) | CA2CA1CA12CA9CA14 | |
| SCHEMBL4735838 | 0.78 | BCL2L1 (0.45) | CA2CA1CA12CA9PTGES2 | |
| SCHEMBL3664099 | 0.76 | BCL2L1 (0.40) | CA2CA1CA12CA9CA14 | |
| SCHEMBL1540298 | 0.71 | HTT (0.45) | KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4733878 | 0.70 | BCL2L1 (0.59) | CA2CA1BCL2L1 | |
| SCHEMBL4731200 | 0.69 | BCL2L1 (0.57) | CA2CA1BCL2L1 | |
| SCHEMBL1540297 | 0.69 | SMN1; SMN2 (0.45) | KMT2AHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1876579 | 0.65 | CA2 (0.50) | CA2CA1CA12CA9CA14 | |
| SCHEMBL3661739 | 0.64 | CA2 (0.56) | CA2CA1CA12CA9PTGES2 | |
| SCHEMBL7144287 | 0.64 | CA2 (0.49) | CA2CA1CA12CA9PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231159-A1 | METHOD OF TREATING ARTHRITIS | Abbott Laboratories (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009064938-A1 | METHOD OF TREATING ARTHRITIS | ABBOTT LABORATORIES (US) | 2009-05-22 | — | — | WO | disclosed |