SCHEMBL3664056

SCHEMBL3664056

COc1ccc(Cl)cc1-c1cccnc1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 3/20 0.44
BACE1 P56817 3/20 0.44
BACE2 Q9Y5Z0 3/20 0.44
REN P00797 1/20 0.44
LRRK2 Q5S007 1/20 0.44
RECQL P46063 1/20 0.44
PDE2A O00408 3/20 0.44
PDE10A Q9Y233 3/20 0.44
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 3/20 0.43
CCNT1 O60563 1/20 0.43
CDK9 P50750 1/20 0.43
PDE5A O76074 1/20 0.43
PDE11A Q9HCR9 1/20 0.43
HPGD P15428 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
USP2 O75604 1/20 0.42
PRNP P04156 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21568383 0.84 ALDH1A1 (0.46) LRRK2RECQLALDH1A1KDM4ECCNT1
SCHEMBL3664647 0.82 ALDH1A1 (0.50) LRRK2RECQLALDH1A1KDM4EMEN1
SCHEMBL7608689 0.78 ERN1 (0.47) LRRK2ALDH1A1KDM4EHPGDMEN1
SCHEMBL7699644 0.78 ALDH1A1 (0.56) LRRK2RECQLALDH1A1KDM4EHPGD
SCHEMBL28864411 0.77 ALDH1A1 (0.54) ALDH1A1KDM4EHPGDMEN1KMT2A
SCHEMBL28695697 0.76 DHODH (0.45) PDE2APDE10ANPC1
SCHEMBL20321559 0.75 HTR7 (0.45) ALDH1A1KDM4EHPGDKMT2ANPSR1
SCHEMBL20406081 0.75 CYP1A2 (0.45) PDE2APDE10AALDH1A1PDE5APDE11A
SCHEMBL3663018 0.75 ALDH1A1 (0.49) RECQLALDH1A1KDM4EHPGDMEN1
SCHEMBL22195968 0.73 ALDH1A1 (0.43) RECQLALDH1A1KDM4EHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2240446-B2 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES UNIVERSAL DISPLAY CORP (US) 2018-09-19 EP disclosed
EP-2240446-B1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES UNIVERSAL DISPLAY CORP (US) 2015-11-11 EP disclosed
US-8221905-B2 Carbazole-containing materials in phosphorescent light emitting diodes UNIVERSAL DISPLAY CORPORATION (US) 2012-07-17 US disclosed
EP-2240446-A2 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES Universal Display Corporation (US) 2010-10-20 EP disclosed
WO-2009086028-A2 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES UNIVERSAL DISPLAY CORPORATION (US) 2009-07-09 WO disclosed
US-20090153034-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTINIG DIODES UNIVERSAL DISPLAY CORPORATION (US) 2009-06-18 US disclosed
US-20090134784-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES UNIVERSAL DISPLAY CORPORATION (US) 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090134784-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES OXA1L, PAICS, ORC3 CTSD 2349/4885BACE1 4064/4885BACE2 3263/4885
US-20090153034-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTINIG DIODES PAICS, CYBA, OXA1L CTSD 1648/4885BACE1 3999/4885BACE2 3088/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.