Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9808215 | 0.90 | LMNA (0.67) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL21507854 | 0.90 | KMT2A (0.48) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL15723552 | 0.86 | MAPK1 (0.58) | LMNAMAPK1SMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL9808100 | 0.84 | DRD2 (0.72) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL196962 | 0.82 | KMT2A (0.68) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL700133 | 0.82 | WDR5 (0.51) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL13096495 | 0.81 | MAPK1 (0.73) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL197632 | 0.81 | KMT2A (0.76) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL366494 | 0.81 | LMNA (0.57) | HTTLMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL3957187 | 0.80 | LMNA (0.61) | HTTLMNAMAPK1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| CN-106459032-B | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-107108606-B | For treating and preventing hepatitis b virus infected new 6,7- dihydrobenzo [a] quinolizine -2- ketone derivatives | 豪夫迈·罗氏有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-106459032-A | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2017-02-22 | — | — | CN | disclosed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| CN-100582108-C | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING PLOUGH ANIMAL HEALTH | 2010-01-20 | — | — | CN | disclosed |
| CN-1922181-A | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING PLOUGH ANIMAL HEALTH (CH) | 2007-02-28 | — | — | CN | disclosed |