Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 5/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649966 | 0.89 | HDAC4 (0.52) | PRKAA2PAK1LIPEKMT2ASLC6A5 | |
| SCHEMBL2506008 | 0.86 | SLC6A5 (0.56) | PRKAA2HPGDSSLC6A5TEAD1 | |
| SCHEMBL16202108 | 0.85 | HPGDS (0.52) | PRKAA2HPGDSSLC6A5 | |
| SCHEMBL651761 | 0.85 | SLC6A5 (0.55) | PRKAA2HPGDSSLC6A5TEAD1 | |
| SCHEMBL646445 | 0.84 | PRKAA2 (0.62) | PRKAA2SLC6A5TEAD1 | |
| SCHEMBL647710 | 0.83 | SLC6A5 (0.53) | PRKAA2SLC6A5TEAD1 | |
| SCHEMBL16194601 | 0.82 | PRKAA2 (0.48) | PRKAA2HPGDSPAK1SLC6A5EPHX2 | |
| SCHEMBL3665469 | 0.82 | LIPG (0.45) | PRKAA2LIPGLIPEGAASMN1; SMN2 | |
| SCHEMBL4441001 | 0.82 | HRH3 (0.48) | PRKAA2PAK1SLC6A5TEAD1 | |
| SCHEMBL648561 | 0.82 | PRKAA2 (0.60) | PRKAA2SLC6A5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |