Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 7/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649734 | 0.89 | GPR119 (0.58) | GPR119SFRP1 | |
| SCHEMBL649826 | 0.89 | PRKAA2 (0.52) | LIPEPRKAA2SFRP1CA12CA1 | |
| SCHEMBL4454172 | 0.89 | USP30 (0.45) | LIPGUCHL1USP30LIPEGPR119 | |
| SCHEMBL10113339 | 0.88 | ALDH1A1 (0.46) | LIPGUCHL1USP30LIPEGPR119 | |
| SCHEMBL648582 | 0.87 | UCHL1 (0.43) | LIPGUCHL1USP30LIPEGPR119 | |
| SCHEMBL648845 | 0.85 | LIPE (0.45) | UCHL1USP30LIPEGPR119PRKAA2 | |
| SCHEMBL650729 | 0.83 | LIPE (0.43) | UCHL1USP30LIPEPRKAA2SMN1; SMN2 | |
| SCHEMBL12225951 | 0.83 | PRKAA2 (0.46) | UCHL1USP30LIPEPRKAA2 | |
| SCHEMBL3665124 | 0.82 | PRKAA2 (0.51) | LIPGLIPEPRKAA2GAASMN1; SMN2 | |
| SCHEMBL4401672 | 0.82 | LIPE (0.44) | UCHL1USP30LIPEGPR119PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |