Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | C5 | P01031 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664810 | 0.84 | MEN1 (0.33) | KIF11KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL675927 | 0.83 | MAP2 (0.36) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3668528 | 0.80 | ERBB2 (0.42) | RAB9ATLR8TLR7HDAC3HDAC1 | |
| SCHEMBL3665277 | 0.80 | MAPT (0.33) | KIF11KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3665283 | 0.79 | KIF11 (0.35) | KIF11ALDH1A1MEN1KMT2AMAPT | |
| Diethylamine SCHEMBL3664811 | 0.78 | HDAC3 (0.35) | KIF11KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL675108 | 0.78 | CA1 (0.46) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL676048 | 0.77 | GSK3B (0.41) | KIF11KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL3665281 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3732599 | 0.77 | CTNNB1 (0.36) | KIF11KDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |