Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675926 | 0.83 | KMT2A (0.35) | MAPTMEN1KMT2AALDH1A1HDAC3 | |
| Diethylamine SCHEMBL3664811 | 0.83 | HDAC3 (0.35) | MAPTMEN1KMT2AALDH1A1GCGR | |
| SCHEMBL3665281 | 0.82 | KDM4E (0.39) | MEN1KMT2AALDH1A1GCGRTLR8 | |
| SCHEMBL3665283 | 0.82 | KIF11 (0.35) | MAPTMEN1KMT2AALDH1A1GCGR | |
| SCHEMBL675224 | 0.82 | ALDH1A1 (0.38) | MAPTMEN1KMT2AALDH1A1GCGR | |
| SCHEMBL678686 | 0.81 | TERT (0.35) | MAPTMEN1KMT2AALDH1A1GCGR | |
| SCHEMBL3668527 | 0.80 | ERBB2 (0.42) | MAPTMEN1KMT2AGCGRTLR8 | |
| SCHEMBL3665280 | 0.80 | KIF11 (0.34) | MAPTMEN1KMT2AALDH1A1GCGR | |
| SCHEMBL3664810 | 0.78 | MEN1 (0.33) | MAPTMEN1KMT2AALDH1A1GCGR | |
| SCHEMBL675108 | 0.78 | CA1 (0.46) | MAPTMEN1KMT2AALDH1A1GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |