Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365016 | 0.87 | KDM4E (0.50) | KMT2ACASP3SENP7SMN1; SMN2KDM4E | |
| SCHEMBL366560 | 0.85 | KDM4E (0.47) | KMT2ACASP3SENP7SMN1; SMN2KDM4E | |
| SCHEMBL365668 | 0.83 | KMT2A (0.55) | KMT2ACASP3SENP7SMN1; SMN2KDM4E | |
| SCHEMBL365101 | 0.82 | KMT2A (0.51) | KMT2ACASP3SENP7SMN1; SMN2KDM4E | |
| SCHEMBL366406 | 0.79 | GABRP (0.41) | KMT2ASMN1; SMN2KDM4ERAB9AALDH1A1 | |
| SCHEMBL364758 | 0.78 | MEN1 (0.44) | KMT2ASMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL365117 | 0.77 | GABRP (0.41) | KMT2ASMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL365562 | 0.76 | CYP3A4 (0.46) | KMT2ASMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL365134 | 0.75 | KMT2A (0.50) | KMT2ACASP3SENP7SMN1; SMN2KDM4E | |
| SCHEMBL365015 | 0.72 | ALDH1A1 (0.58) | KMT2ACASP3SENP7SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |