Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365101 | 0.90 | KMT2A (0.51) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL365016 | 0.85 | KDM4E (0.50) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL366561 | 0.83 | KMT2A (0.45) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL367409 | 0.83 | EPHX1 (0.48) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL365667 | 0.82 | EPHX1 (0.56) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL365134 | 0.82 | KMT2A (0.50) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL366114 | 0.80 | TSHR (0.47) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL367333 | 0.80 | HPGD (0.52) | KMT2ASMN1; SMN2KDM4ECYP1A2TSHR | |
| SCHEMBL366310 | 0.79 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL365264 | 0.75 | EPHX1 (0.45) | KMT2ASMN1; SMN2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |