Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571690 | 0.91 | PKM (0.42) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL1863608 | 0.82 | PKM (0.68) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL10859847 | 0.80 | KMT2A (0.41) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL7333555 | 0.76 | PKM (0.35) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL11257336 | 0.75 | PKM (0.39) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL30371888 | 0.75 | PKM (0.37) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL5607969 | 0.73 | NAALAD2 (0.47) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL28759662 | 0.73 | MEN1 (0.30) | THRBALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL13544391 | 0.73 | NAALAD2 (0.47) | PKMKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL17439190 | 0.73 | PKM (0.35) | PKMKDM4ETHRBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994853-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998051662-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 1998-11-19 | — | — | WO | claimed |
| EP-0035949-B1 | TEXTILE FILTER FOR FLOWS OF GAS COMPRISING ORGANIC FIBRES GRAFTED WITH ACTIVE MONOMERS | DOLLFUS & NOACK (FR) | 1984-09-19 | — | — | EP | claimed |
| WO-1981002530-A1 | TEXTILE FILTER FOR GAS FLOW,COMPRISING ORGANIC FIBERS GRAFTED WITH ACTIVE MONOMERS | DOLLFUS & NOACK (FR) | 1981-09-17 | — | — | WO | claimed |
| EP-0035949-A1 | Textile filter for flows of gas comprising organic fibres grafted with active monomers | DOLLFUS & NOACK (FR) | 1981-09-16 | — | — | EP | claimed |
| CN-218653046-U | Rectification equipment of acetoacetic acid aminoethyl ester | 北京世纪迈劲生物科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-115541734-A | Method for determining protected amino acid enantiomer by normal phase chromatography | 南京锐志生物医药有限公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-113121378-B | Synthesis method of acetamino diethyl malonate | 湖北宇阳药业有限公司 | 2022-12-02 | — | — | CN | disclosed |
| EP-3658546-B1 | INDOLE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2022-10-26 | — | — | EP | disclosed |
| CN-113121378-A | Synthesis method of acetamino diethyl malonate | 湖北宇阳药业有限公司 | 2021-07-16 | — | — | CN | disclosed |
| EP-3658546-A1 | INDOLE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2020-06-03 | — | — | EP | disclosed |
| US-10654828-B2 | Indole derivatives and uses thereof | NOVARTIS AG (CH) | 2020-05-19 | — | — | US | disclosed |
| CN-1876621-A | Novel process for preparing acetamino diethyl malonate | ANHUI HORAE NEW TECHNOLOGY DEV (CN) | 2006-12-13 | — | — | CN | disclosed |
| US-6875419-B2 | Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-04-05 | — | — | US | disclosed |
| EP-1390079-A2 | PARAMAGNETIC METAL ION-BASED MACROCYLIC CONTRAST AGENTS | Board of Regents University of Texas System (US) | 2004-02-25 | — | — | EP | disclosed |
| US-20020127182-A1 | Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2002-09-12 | — | — | US | disclosed |
| WO-2002043775-A2 | PARAMAGNETIC METAL ION-BASED MACROCYCLIC CONTRAST AGENTS | GODFREY, Cullen, M. (US) | 2002-06-06 | — | — | WO | disclosed |
| US-4873253-A | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0284632-A1 | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1988-10-05 | — | — | EP | disclosed |
| EP-0035949-B1 | TEXTILE FILTER FOR FLOWS OF GAS COMPRISING ORGANIC FIBRES GRAFTED WITH ACTIVE MONOMERS | DOLLFUS & NOACK (FR) | 1984-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020127182-A1 | Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use | MTCH2, HRH3, HRH1 | PKM 854/4885KDM4E 4384/4885THRB 503/4885 |
| US-10654828-B2 | Indole derivatives and uses thereof | MYLK2, MYOF, MUSK | PKM 1550/4885KDM4E 2754/4885THRB 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.